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Zachary Bessette
Zachary Bessette
Articles by Zachary Bessette
TALAPRO-2: Final OS After First-Line Treatment for Patients With mCRPC
Zachary Bessette
CRPC
|
February 13, 2025
Tala/enza demonstrated improvement in OS compared with enza alone as 1L treatment in patients with mCRPC.
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CheckMate 214: Evaluating KIM-1 as a Biomarker in Advanced RCC
Zachary Bessette
Renal Cell Carcinoma
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February 18, 2025
Increased levels of circulating KIM-1 are associated with worse outcomes for patients receiving nivo/ipi or sunitinib alone.
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FDA Approves Nivolumab and Hyaluronidase-nvhy for Subcutaneous Injection
Zachary Bessette
Renal Cell Carcinoma
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January 2, 2025
The FDA has approved nivo for subcutaneous injection for all solid tumors for which nivo is indicated as a monotherapy.
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CONTACT-02: Final OS Results of Cabo/Atezo Versus Second Novel Hormonal Therapy for mCRPC
Zachary Bessette
CRPC
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October 1, 2024
The final results of the CONTACT-02 trial show favorable, but not statistically significant, benefit for cabo/atezo in mCRPC.
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NIAGARA Offers Paradigm-Shift for Neoadjuvant Treatment of MIBC
Zachary Bessette
Muscle Invasive Urothelial Carcinoma
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September 17, 2024
Perioperative durvalumab with NAC offers “meaningful improvement” in EFS and OS for patients with cisplatin-ineligible ...
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SunRISe-1: TAR-200, Cetrelimab for BCG-Unresponsive High-Risk NMIBC
Zachary Bessette
Non-Muscle Invasive Urothelial Carcinoma
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September 17, 2024
Results of SunRISe-1 provide support for TAR-200 monotherapy in patients with BCG-unresponsive high-risk NMIBC.
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EV-302: Nectin-4 Expression and Response to First-Line EV/Pembro
Zachary Bessette
Advanced Urothelial Carcinoma
|
September 13, 2024
EV/pembro may offer first-line PFS and OS benefit in patients with la/mUC, regardless of Nectin-4 expression.
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Futibatinib Plus Pembrolizumab for Patients With Metastatic Urothelial Carcinoma
Zachary Bessette
Advanced Urothelial Carcinoma
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September 12, 2024
A phase 2 study highlights the “encouraging” antitumor activity from futibatinib plus pembrolizumab for patients with ...
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Nivo, Chemoradiotherapy for Patients With nmMIBC Not Undergoing Cystectomy
Zachary Bessette
Muscle Invasive Urothelial Carcinoma
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September 11, 2024
The addition of nivo to trimodality therapy may improve RFS in patients with non-metastatic muscle-invasive bladder cancer.
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FDA Accepts New Drug Application for Prostate Cancer Imaging Agent
Zachary Bessette
Prostate Cancer Diagnostics
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July 24, 2024
The FDA has accepted an NDA for TLX007-CDx, a cold kit for the preparation of PSMA-PET imaging for prostate cancer.
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PSMA Tandem Treatment Offers Benefit for Patients With mCRPC
Zachary Bessette
RLT
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June 11, 2024
A phase 3 trial offers the first randomized evidence of the benefit of PSMA tandem therapy in patients with mCRPC.
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18F-rhPSMA-7 Versus Conventional Salvage Radiotherapy for BCR
Zachary Bessette
Prostate Cancer Diagnostics
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June 11, 2024
New research provides evidence of 18F-rhPSMA-7 leading to more favorable disease outcomes for patients with BCR after RP.
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NEPTUNES: Nivolumab, Ipilimumab for Metastatic Prostate Cancer With an Immunogenic Signature
Zachary Bessette
CRPC
|
June 4, 2024
Dr. Mark David Linch presented the results of NEPTUNES: a multicenter, 2-cohot, biomarker-selected, phase 2 trial.
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CHAARTED2: Cabazitaxel Plus Abiraterone After Initial Docetaxel for mCRPC
Zachary Bessette
CRPC
|
June 3, 2024
Results from the CHAARTED2 trial was presented by Dr. Kyriakopoulos of the University of Wisconsin Carbone Cancer Center.
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SURE-01/02: Perioperative Sacituzumab Govitecan for Patients With MIBC
Zachary Bessette
Muscle Invasive Urothelial Carcinoma
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June 1, 2024
Neoadjuvant SG shows promising clinical activity in patients with MIBC and may help avoid radical cystectomy.
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HERCULES: Pembrolizumab Plus Platinum-Based Chemotherapy for First-line Advanced Penile Cancer
Zachary Bessette
Testicular, Penile, and Rare Malignancies
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May 31, 2024
A recent trial provides the first evidence of efficacy from ICIs in PSCC with a manageable safety profile.
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NABUCCO Update: Efficacy, Biomarker Analysis of Preoperative Ipilimumab Plus Nivolumab
Zachary Bessette
Advanced Urothelial Carcinoma
|
May 31, 2024
An update on clinical efficacy and an exploratory biomarker analysis from the NABUCCO trial for patients with stage III UC.
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First-line RCC Systemic Therapy Following Adjuvant Immunotherapy
Zachary Bessette
Advanced Renal Cell Carcinoma
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June 10, 2024
Patients with RCC who experience disease recurrence after adjuvant IO benefit from subsequent systemic therapies.
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High-Dose Chemotherapy Outcomes in Men With Germ Cell Cancer
Zachary Bessette
Testicular, Penile, and Rare Malignancies
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May 31, 2024
The SWENOTECA cancer care program sought to evaluate survival, toxicity in patients treated with HDCT from 2011 through 2021.
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EMBARK: Post Hoc Analysis of Impact of Treatment Suspension on HRQOL
Zachary Bessette
Localized
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May 31, 2024
Researchers attempted to confirm whether treatment suspension for EMBARK patients may lead to improvements in HRQOL.
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