Jordan Alana Ciuro, MD, breaks down key factors to consider when determining whether to treat mHSPC with a doublet or triplet regimen, including disease burden, patient fitness, toxicity, and accessibility. Dr. Ciuro reviews findings from CHAARTED, STAMPEDE, TITAN, ENZAMET, ARASENS, and PEACE-1, highlighting when ADT with an ARSI is sufficient and when adding chemotherapy (docetaxel) may improve survival.