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Doublet vs Triplet Therapy for mHSPC: Patient Selection and Treatment Considerations

By Jordan Ciuro, MD - Last Updated: February 28, 2025

Jordan Alana Ciuro, MD, breaks down key factors to consider when determining whether to treat mHSPC with a doublet or triplet regimen, including disease burden, patient fitness, toxicity, and accessibility. Dr. Ciuro reviews findings from CHAARTED, STAMPEDE, TITAN, ENZAMET, ARASENS, and PEACE-1, highlighting when ADT with an ARSI is sufficient and when adding chemotherapy (docetaxel) may improve survival.