At the American Society of Clinical Oncology Genitourinary Cancer Symposium, Karen Hoffman, MD, MHSc, MPH, University of Texas MD Anderson Cancer Center, and Christopher Wallis, MD, PhD, FRCSC, University of Toronto, discuss the updated patient-level data of the FORMULA-509 trial, showing that abiraterone acetate plus prednisone and apalutamide improve prostate cancer outcomes without causing a detectable difference in patient-reported hormonal function, fatigue, or mental status.