At the 2025 American Society of Clinical Oncology Genitourinary Cancers Symposium, Morgan Roupret, MD, of Hopital Pitié-Salpétrière, and Nadine Houede, MD, of Montpellier University, dissect their research on the safety and efficacy of neoadjuvant immunotherapy with durvalumab in combination with neoadjuvant gemcitabine/cisplatin or carboplatin in patients with operable high-risk upper tract urothelial carcinoma.