Proteinuria Incidence After Radical Versus Partial Nephrectomy

New research has analyzed the incidence and impact of proteinuria in patients following radical and partial nephrectomy. While previous research has investigated the incidence of proteinuria after nephrectomy, a direct comparison between radical and partial nephrectomy is lacking.

The retrospective study utilized clinical data from 310 patients who underwent radical or partial nephrectomy at a single center between 2014 and 2022. Radical nephrectomy was more common among patients than partial nephrectomy (60.6% vs 31.9%).

After surgery, a notable decline in estimated glomerular filtration rate (eGFR) occurred in patients who underwent radical nephrectomy at one to three months (73.09 mL/minute) compared to partial nephrectomy (90.99 mL/minute) (P<0.001), with similar trends at 6-12 months.

The mortality rate was 1.6% (n=5), and significant associations were seen between preoperative eGFR and mortality (P=.008). Proteinuria post-nephrectomy was observed in 27.1% patients (n=84), with significant differences in proteinuria levels between radical (107.10 mg/dL) and partial nephrectomy (62.80 mg/dL) (P=.031).

Radical nephrectomy was associated with a greater decline in postoperative eGFR compared with partial nephrectomy, and proteinuria was significantly higher in patients who underwent radical nephrectomy.

As preoperative eGFR was linked to a greater mortality risk, this study highlights the need for careful monitoring in high-risk patients. This data can provide valuable insight into post-surgical outcomes for guiding treatment approaches and patient care.