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The Phase 3 CLARIFY Trial With 64Cu-SAR-bisPSMA: A Next-Generation PSMA Imaging Agent

By David Morris, MD, FACS - Last Updated: January 6, 2025

David Morris, MD, FACS, of Urology Associates of Nashville, discusses the emerging role of copper-based PSMA imaging agents, specifically Clarity Pharmaceuticals’ 64Cu-SAR-bisPSMA, in prostate cancer diagnostics.

He highlights the unique dual-binding structure of this tracer, which may offer increased sensitivity and specificity compared to gallium-based PSMA tracers. The conversation explores the clinical benefits of same-day and next-day imaging, which allows for more flexible scheduling and may enhance detection of smaller nodal metastases.