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Brandon Twyford
Brandon Twyford is the Senior Editor for GU Oncology Now
Articles by Brandon Twyford
Final TALAPRO-2 Analysis: Talazoparib Plus Enzalutamide Significantly Improves Survival in HRR-Deficient mCRPC
Brandon Twyford
CRPC
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February 21, 2025
Final TALAPRO-2 results show talazoparib + enzalutamide significantly improves survival in patients with HRR-deficient mCRPC.
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Patient-Reported Outcomes From TiNivo-2 Highlight Quality-of-Life Considerations in RCC Treatment
Brandon Twyford
Renal Cell Carcinoma
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February 18, 2025
The study found no PFS benefit for tivozanib plus nivolumab in RCC post-ICI, but tivozanib maintained quality of life.
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Neoadjuvant Durvalumab Plus Chemotherapy Shows Promise in Upper Tract Urothelial Carcinoma
Brandon Twyford
Urothelial Carcinoma
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February 18, 2025
Neoadjuvant durvalumab plus chemotherapy shows promising pathologic response rates, favorable safety profile in UTUC.
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EV-302: Updated Analysis Reinforces Enfortumab Vedotin Plus Pembrolizumab as Standard of Care in Advanced Urothelial Carcinoma
Brandon Twyford
Urothelial Carcinoma
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February 18, 2025
EV+P continues to show superior efficacy and durable responses in previously untreated locally advanced or metastatic UC.
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KEYMAKER-U03 Substudy 03B: Evaluating Pembrolizumab and Targeted Therapy Combinations in Advanced Clear Cell RCC
Brandon Twyford
Renal Cell Carcinoma
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February 14, 2025
The study found promising results with lenvatinib + belzutifan for patients with previously treated RCC.
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Radiotherapy Results in Lower Risk of Distant Metastasis in High-Risk Prostate Cancer Compared With Radical Prostatectomy
Brandon Twyford
Prostate Cancer
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February 12, 2025
Radiotherapy may reduce distant metastasis risk in high-risk prostate cancer compared to surgery, according to new study.
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Clarity Pharmaceuticals Receives FDA Fast Track Designation for Cu-64 SAR-bisPSMA Prostate Cancer Imaging Agent
Brandon Twyford
Prostate Cancer Diagnostics
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January 24, 2025
The FDA's Fast Track Designation enables expedited development of 64Cu-SAR-bisPSMA for recurrent prostate cancer imaging.
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Durvalumab Granted Priority Review by FDA for Muscle-Invasive Bladder Cancer Treatment
Brandon Twyford
Muscle Invasive Urothelial Carcinoma
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December 6, 2024
Durvalumab was granted FDA Priority Review for MIBC, after showing significant survival benefits in the NIAGARA trial.
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Protara Announces Promising Phase 2 Results for TARA-002 in High-Risk NMIBC
Brandon Twyford
Non-Muscle Invasive Urothelial Carcinoma
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December 6, 2024
TARA-002 shows promising efficacy, safety in the ADVANCED-2 trial for NMIBC, with high response rates across BCG exposures.
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Ferring Advances Clinical Trials for ADSTILADRIN in Bladder and Upper Tract Urothelial Cancers
Brandon Twyford
Non-Muscle Invasive Urothelial Carcinoma
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December 4, 2024
Ferring has advanced three clinical trials assessing nadofaragene as a monotherapy and combination therapy for NMIBC.
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CG Oncology to Showcase Phase 3 Results and Ongoing Trials on Cretostimogene Grenadenorepvec at SUO 2024
Brandon Twyford
Non-Muscle Invasive Urothelial Carcinoma
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December 3, 2024
Several posters and a late-breaking abstract will highlight data on cretostimogene grenadenorepvec for bladder cancer.
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Real-World Results of Olaparib for HRRm+ Castration-Resistant Prostate Cancer
Brandon Twyford
CRPC
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December 3, 2024
The real-world analysis of olaparib for HRRm+ CRPC showed that earlier treatment resulted in higher PFS and OS.
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Prognostic Potential of ctDNA in Lymph Node-Positive Bladder Cancer Post-RARC
Brandon Twyford
Muscle Invasive Urothelial Carcinoma
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December 3, 2024
The study examined the prognostic value of ctDNA as a biomarker in patients with muscle-invasive bladder cancer.
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ImmunityBio Announces Key Milestone With ANKTIVA in BCG-Unresponsive NMIBC CIS Trial
Brandon Twyford
Non-Muscle Invasive Urothelial Carcinoma
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November 19, 2024
ANKTIVA plus BCG shows a 71% CR rate and up to 54 months of durable response in patients with BCG-unresponsive NMIBC-CIS.
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Clarity Pharmaceuticals Launches Head-to-Head Diagnostic Trial for Prostate Cancer Recurrence
Brandon Twyford
Prostate Cancer Diagnostics
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November 18, 2024
Clarity's head-to-head trial evaluates diagnostic performance of 64Cu-SAR-bisPSMA vs 68Ga-PSMA-11.
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Clarity Pharmaceuticals’ COBRA Study Selected as Top-Rated Oral Presentation at EANM 2024
Brandon Twyford
Prostate Cancer Diagnostics
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October 2, 2024
The COBRA study on SAR-bisPSMA for prostate cancer detection will be presented at the EANM 2024 Congress.
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TiNivo-2: Tivozanib-Nivolumab Combination Fails to Improve PFS in Advanced RCC Compared to Tivozanib Monotherapy
Brandon Twyford
Advanced Renal Cell Carcinoma
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September 17, 2024
The TiNivo-2 trial found that a tivozanib-nivolumab combination therapy did not improve outcomes over tivozanib alone.
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TOMBOLA: ctDNA Testing Identifies Patients With Bladder Cancer Who May Benefit From Early Immunotherapy
Brandon Twyford
Muscle Invasive Urothelial Carcinoma
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September 16, 2024
ctDNA testing may help identify patients with bladder cancer who would benefit from early post-cystectomy immunotherapy.
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Promising Early Results for Disitamab Vedotin and Pembrolizumab Combo in HER2-Positive Urothelial Cancer
Brandon Twyford
Advanced Urothelial Carcinoma
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September 12, 2024
Disitamab vedotin plus pembrolizumab shows promising efficacy, manageable safety in HER2+ aUC, with a 61.1% response rate.
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New Conference Aims to Develop Consensus on Kidney, Bladder Cancer Management
Brandon Twyford
AUC3
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August 8, 2024
AUC3 seeks to reshape the landscape of GU cancer management through interdisciplinary dialogue and consensus building.
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